S7-1500 OB122 I/O access error (16#42) in RUN, what to check?

Question

I'm getting an OB122 I/O access error (16#42) on my S7-1500 CPU, but the CPU stays in RUN. It's a read error, and I suspect it's related to direct I/O access. What should I check first?

Top answer · Written by InduQT from the fault guide and manufacturer manuals cited below · Oct 28, 2026

An OB122 I/O access error on a Siemens S7-1500 CPU indicates a problem during direct access to I/O data, such as reading from an input module. The CPU will remain in RUN and log a diagnostics buffer entry. A 16#42 fault ID specifically points to a read error. This typically occurs when the program attempts to access an I/O module that is unavailable or incorrectly configured.

Likely causes and checks

1Module or station not available

Points to it
The program is attempting direct access to an I/O module or an entire station that is not currently available or online.
Check
Check the status of the module or station in 'Online & diagnostics' in the programming software. Look for accompanying OB83 or OB86 events in the diagnostics buffer, as these often point to hardware availability issues.

2Direct access to an unconfigured address

Points to it
The program is trying to directly read or write to an I/O address for which no module is configured in the hardware setup.
Check
Compare the I/O address specified in the program (e.g., %IW…:P) with the actual hardware configuration to ensure a module is assigned to that address. If the error repeats every cycle at the same address, this is a strong indicator.

Next check: After checking module availability and configuration, review the program logic to understand how it handles failed I/O access, especially for read errors (16#42), as the program did not receive a valid input value.

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